掲載論文など
原著論文・総説など
2023
Hara S, Inoue Y, Aoki S, Tanaka K, Shirasuna K, Iwata H.
Beneficial Effect of Polysaccharide Gel Made of Xanthan Gum and Locust Bean Gum on Bovine Oocytes
Int J Mol Sci. 2023 Feb 9;24(4):3508. doi: 10.3390/ijms24043508.
Ito J, Kageyama M, Hara S, Sato T, Shirasuna K, Iwata H.
Paternal aging impacts mitochondrial DNA content and telomere length in mouse embryos
Mitochondrion. 2023 Jan;68:105-113. doi: 10.1016/j.mito.2022.12.002.
Kondo R, Ozawa R, Satomi T, Funabayashi K, Iwata H, Kuwayama T, Shirasuna K.
Severe maternal stress alters placental function, resulting in adipose tissue and liver dysfunction in offspring of mice
Mol Cell Endocrinol. 2023 Jan 15;560:111814. doi: 10.1016/j.mce.2022.111814.
樽 舞帆、加藤 大雅、三浦 亮太朗、濱野 晴三、白砂 孔明
長期不受胎牛の繁殖対策と特徴を考える
臨床獣医 2023 2月号
2022
原著論文
Nagata S, Inoue Y, Sato T, Tanaka K, Shinozawa A, Shirasuna K, Iwata H.
Age-associated changes in miRNA profile of bovine follicular fluid
Reproduction 2022 Oct 10;164(5):195-206. doi: 10.1530/REP-22-0036
Predicting of molecules mediating an interaction between bovine embryos and uterine epithelial cells
J Reprod Dev 2022 Oct 6;68(5):318-323.doi: 10.1262/jrd.2022-046.
Noguchi T, Hayashi T, Inoue Y, Hara S, Shirasuna K, Iwata H.
Aoki S, Inoue Y, Shinozawa A, Tanaka K, Shirasuna K, Iwata H.
miR-17-5p in bovine oviductal fluid affects embryo development
Mol Cell Endocrinol. 2022 Jul 1;551:111651. doi: 10.1016/j.mce.2022.111651.
Sano M, Komiyama H, Shinoda R, Ozawa R, Watanabe H, Karasawa T, Takahashi M, Torii Y, Iwata H, Kuwayama T, Shirasuna K.
NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice
Am J Reprod Immunol. 2022 Feb 11:e13527. doi: 10.1111/aji.13527.
Onizawa Y, Katoh T, Miura R, Konda K, Noguchi T, Iwata H, Kuwayama T, Hamano S, Shirasuna K.
Acetoacetate is a trigger of NLRP3 inflammasome activation in bovine peripheral blood mononuclear cells
Vet Immunol Immunopathol. 2022 Feb;244:110370. doi: 10.1016/j.vetimm.2021.110370
総説
Iwata H.
Resveratrol enhanced mitochondrial recovery from cryopreservation‐induced damages in oocytes and embryos.
Reprod Med Biol. 2021 Jun 27; 20(4):419-426. doi: 10.1002/rmb2.1240
伊藤洵、岩田尚孝
凍結に由来するミトコンドリア障害からの胚の回復
JMOR, 38(1) 25-29, 2021
2020
原著論文
Y. Nakamura, R. Aihara, H. Iwata, T. Kuwayama, K. Shirasuna.
IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2. Am J Reprod Immunol. 2020. e13365. doi: 10.1111/aji.13365.
M. Kobayashi, J. Kobayashi, K. Shirasuna, H. Iwata.
Abundance of cell-free mitochondrial DNA in spent culture medium associated with morphokinetics and blastocyst collapse of expanded blastocysts. Reprod Med Biol. 2020. 19(4):404-414. doi: 10.1002/rmb2.12344.
S. Nagata, K. Tatematsu, K. Kansaku, Y. Inoue, M. Kobayashi, K. Shirasuna, H. Iwata.
Effect of aging on mitochondria and metabolism of bovine granulosa cells. J Reprod Dev. 2020. Online ahead of print. doi: 10.1262/jrd.2020-071.
M. Kobayashi, J. Ito, K. Shirasuna, T. Kuwayama, H. Iwata.
Comparative analysis of cell-free DNA content in culture medium and mitochondrial DNA copy number in porcine parthenogenetically activated embryos. J Reprod Dev. 2020. Online ahead of print. doi: 10.1262/jrd.2020-097.
Y. Inoue, Y. Munakata, A. Shinozawa, R. Kawahara-Miki, K. Shirasuna, H. Iwata.
Prediction of major microRNAs in follicular fluid regulating porcine oocyte development. J Assist Reprod Genet. 2020. 37(10):2569-2579. doi: 10.1007/s10815-020-01909-0.
S. Nagayama, K. Shirasuna, M. Nagayama, S. Nishimura, M. Takahashi, S. Matsubara, A. Ohkuchi.
Decreased circulating levels of plasmacytoid dendritic cells in women with early-onset preeclampsia. J Reprod Immunol. 2020. 141:103170. doi: 10.1016/j.jri.2020.103170.
S. Hara, S. Aoki, M. Nagata, K. Shirasuna, T. Noguchi, H. Iwata.
Xanthan gum and locust bean gum substrate improves bovine embryo development. Reprod Domest Anim. 2020. Online ahead of print. doi: 10.1111/rda.13750.
J. Ito, K. Shirasuna, T. Kuwayama, H. Iwata.
Resveratrol treatment increases mitochondrial biogenesis and improves viability of porcine germinal-vesicle stage vitrified-warmed oocytes. Cryobiology. 2020. 93:37-43. doi: 10.1016/j.cryobiol.2020.02.014.
M. Sano, S. Shimazaki, Y. Kaneko, T. Karasawa, M. Takahashi, A. Ohkuchi, H. Takahashi, A. Kurosawa, Y. Torii, H. Iwata, T. Kuwayama, K. Shirasuna.
Palmitic acid activates NLRP3 inflammasome and induces placental inflammation during pregnancy in mice. J Reprod Dev. 2020. 66(3):241-248. doi: 10.1262/jrd.2020-007.
N. Funeshima, N. Tanikawa, H. Yaginuma, H. Watanabe, H. Iwata, T. Kuwayama, S. Hamano, K. Shirasuna.
Adverse reproductive effects of S100A9 on bovine sperm and early embryonic development in vitro. PLoS One. 2020. 15(1):e0227885. doi: 10.1371/journal.pone.0227885.
A, Ishiguro, H, Sakai, K, Kansaku, K, Shirasuna, H, Iwata.
Effect of cryopreservation on the ability of granulosa cells to support in vitro development of oocytes derived from porcine early antral follicles. Theriogenology. 2020. 143:50-56. doi: 10.1016/j.theriogenology.2019.11.038.
伊藤 洵, 久保 穂乃佳, 中村 慎佑, 岩田 尚孝
ガラス化前のレスベラトロール処理がミトコンドリアとウシ胚発生に及ぼす影響. J. Mamm. Ova Res. 2020. 37(1): 23-30.
2021
原著論文
Oogaki Y, Ozawa R, Seshima K, Shinoda R, Torii Y, Takahashi H, Iwata H, Kuwayama T, Shirasuna K.
Uncaria tomentosa extract (AC-11) improves pregnancy hypertension together with suppression of sFlt-1 and sEng
Pregnancy Hypertens. 2021 Dec;26:127-132. doi: 10.1016/j.preghy.2021.10.013.
Nagata S, Tatematsu K, Yamaguchi H, Inoue Y, Tanaka K, Tasaki H, Shirasuna K, Iwata H.
Effect of docosahexaenoic acid on in vitro growth of bovine oocytes
Reprod Med Biol. 2021 Jul 12;20(4):485-493. doi: 10.1002/rmb2.12403.
Hirata Y, Shimazaki S, Suzuki S, Henmi Y, Komiyama H, Kuwayama T, Iwata H, Karasawa T, Takahashi M, Takahashi H, Shirasuna K.
β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption
J Reprod Immunol. 2021 Nov;148:103433. doi: 10.1016/j.jri.2021.103433.
Hikata K, Morohashi N, Taru M, Suzuki Y, Nakamura T, Takeda M, Kuwayama T, Shirasuna K.
Dynamics of plasma sex steroid hormones during multiple pregnancies in the same pair breeding of southern tamandua (Tamandua tetradactyla)
Jpn J Zoo Wild Med. 2021 26: 127-134.
Hirata Y, Katsukura Y, Henmi Y, Ozawa R, Shimazaki S, Kurosawa A, Torii Y, Takahashi H, Iwata H, Kuwayama T, Shirasuna K.
Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in mice. J Reprod Dev. 2021 Aug 27;67(4):257-264. doi: 10.1262/jrd.2021-034. Epub 2021 Jun 28
Ozeki A, Oogaki Y, Henmi Y, Karasawa T, Takahashi M, Takahashi H, Ohkuchi A, Shirasuna K.
Elevated S100A9 in preeclampsia induces soluble endoglin and IL-1β secretion and hypertension via the NLRP3 inflammasome. J Hypertens. 2021 Aug 18. doi: 10.1097/HJH.0000000000002981
Sugimoto A, Inoue Y, Tanaka K, Sinozawa A, Shirasuna K, Iwata H.
Effects of a gel culture system made of polysaccharides (xanthan gum and locust bean gum) on in vitro bovine oocyte development and gene expression of the granulosa cells. Mol Reprod Dev. 2021 Jul;88(7):516-524. doi: 10.1002/mrd.23518.
Aoki S, Ito J, Hara S, Shirasuna K, Iwata H.
Effect of maternal aging and vitrification on mitochondrial DNA copy number in embryos and spent culture medium.
Reprod Biol. 2021 Jun;21(2):100506. doi: 10.1016/j.repbio.2021.100506
Funeshima N, Miura R, Katoh T, Yaginuma H, Kitou T, Yoshimura I, Konda K, Hamano S, Shirasuna K.
Metabolomic profiles of plasma and uterine luminal fluids from healthy and repeat breeder Holstein cows.
BMC Vet Res. 2021 Jan 28;17(1):54. doi: 10.1186/s12917-021-02755-7
M. Kageyama, J. Ito, K. Shirasuna, T. Kuwayama. H. Iwata.
Mitochondrial reactive oxygen species regulate mitochondrial biogenesis in porcine embryos. J Reprod Dev. 2021. doi: 10.1262/jrd.2020-111.
総説
K. Shirasuna, T. Karasawa, M. Takahashi.
Role of the NLRP3 Inflammasome in Preeclampsia. Front Endocrinol (Lausanne). 2020. 25;11:80. doi: 10.3389/fendo.2020.00080.
AK. Talukder, MA. Marey, K. Shirasuna, K. Kusama, M. Shimada, K. Imakawa, A. Miyamoto.
Roadmap to pregnancy in the first 7 days post-insemination in the cow: Immune crosstalk in the corpus luteum, oviduct, and uterus. Theriogenology. 2020 Jul 1(150): 313-320. doi: 10.1016/j.theriogenology.2020.01.071.
2019
原著論文
K. Ichikawa, H. Shibahara, K. Shirasuna, T. Kuwayama, H. Iwata.
Cell-free DNA content in follicular fluid: A marker for the developmental ability of porcine oocytes. Reprod Med Biol. 2019. 19(1):95-103. doi: 10.1002/rmb2.12309.
Y. Munakata, A. Sugimoto, K. Shirasuna, T. Kuwayama, H. Iwata.
Xanthan gum and Locust bean gum gel supports in vitro development of porcine oocytes derived from early antral follicles. J Reprod Dev. 2019. 65(6): 551-554. doi: 10.1262/jrd.2019-074.
K. Kansaku, Y. Munakata, K. Shirasuna, T. Kuwayama, H. Iwata.
Mitochondrial cell-free DNA secreted from porcine granulosa cells. Zygote. 2019. 27(5):272-278. doi: 10.1017/S096719941900025X.
A. Ozeki, K. Tani, H. Takahashi, H. Suzuki, S. Nagayama, C. Hirashima, H. Iwata, T. Kuwayama, A. Ohkuchi, K. Shirasuna.
Preeclamptic patient-derived circulating cell-free DNA activates the production of inflammatory cytokines via toll-like receptor 9 signalling in the human placenta. J Hypertens. 2019. 37(12):2452-2460. doi: 10.1097/HJH.0000000000002208.
N. Funeshima, T. Noguchi, Y. Onizawa, H. Yaginuma, M. Miyamura, H. Tsuchiya, H. Iwata, T. Kuwayama, S. Hamano, K. Shirasuna.
The transfer of parthenogenetic embryos following artificial insemination in cows can enhance pregnancy recognition via the secretion of interferon tau. J Reprod Dev. 2019. 23;65(5):443-450. doi: 10.1262/jrd.2019-026. Epub 2019 Aug 3.
H. Shibahara, A. Ishiguro, K. Shirasuna, T. Kuwayama, H. Iwata.
Follicular factors determining the developmental competence of porcine oocyte. Reprod Med Biol. 2019. 10;18(3):256-262. doi: 10.1002/rmb2.12269. eCollection 2019 Jul.
Y. Nakamura, H. Iwata, T. Kuwayama, K. Shirasuna.
S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells. Am J Reprod Immunol. 2019. 82(3):e13163. doi: 10.1111/aji.13163. Epub 2019 Jul 10.
Y. Kaneko , M. Sano , K. Seno , Y. Oogaki, H. Takahashi, A. Ohkuchi, M. Yokozawa, K. Yamauchi, H. Iwata, T. Kuwayama, K. Shirasuna.
Olive Leaf Extract (OleaVita) Suppresses Inflammatory Cytokine Production and NLRP3 Inflammasomes in Human Placenta. Nutrients. 2019. 28;11(5):970. doi: 10.3390/nu11050970.
H. Shibahara, Y. Munakata, A. Ishiguro, K. Shirasuna, T. Kuwayama, H. Iwata.
Modification of the medium volume and gel substrate under in vitro culture conditions improves growth of porcine oocytes derived from early antral follicles.J Reprod Dev. 2019. 9;65(4):375-379. doi: 10.1262/jrd.2019-012. Epub 2019 Apr 14.
H. Yaginuma, N. Funeshima, N. Tanikawa, M. Miyamura, H. Tsuchiya, T. Noguchi, H. Iwata, T. Kuwayama, K. Shirasuna, S. Hamano.
Improvement of fertility in repeat breeder dairy cattle by embryo transfer following artificial insemination: possibility of interferon tau replenishment effect. J Reprod Dev. 2019. 14;65(3):223-229. doi: 10.1262/jrd.2018-121. Epub 2019 Feb 8
Y. Munakata, K. Shirasuna, T. Kuwayama, H. Iwata.
Cell-free DNA in medium is associated with the maturation ability of in vitro cultured oocytes. J Reprod Dev. 2019. 12;65(2):171-175. doi: 10.1262/jrd.2018-123. Epub 2019 Feb 11.
2018
原著論文
A. Ishiguro, Y. Munakata, K. Shirasuna, T. Kuwayama, H. Iwata.
Addition of granulosa cells collected from differential follicle stages supports development of oocytes derived from porcine early antral follicles. Reprod Med Biol. 2018.
T. Hara, A. Kin, S. Aoki, S. Nakamura, K. Shirasuna, T. Kuwayama, H. Iwata.
Resveratrol enhances the clearance of mitochondrial damage by vitrification and improves the development of vitrified-warmed bovine embryos. PLoS One. 2018.
K. Seno, Y. Munakata, M. Sano, RM. Kawahara, H. Takahashi, A. Ohkuchi, H. Iwata, T. Kuwayama, K. Shirasuna.
Aggregation of human trophoblast cells into three-dimensional culture system enhances anti-inflammatory characteristics through cytoskeleton regulation. International Journal of Molecular Sciences. 2018.
K. Hori, S. Matsuyama, S. Nakamura, H. Iwata, T. Kuwayama, A. Miyamoto, K. Shirasuna.
Age-Related Changes in the Bovine Corpus Luteum Function and Progesterone Secretion. Reproduction in Domestic Animals. 2018.
Y. Munakata, M. Ueda, R. Kawahara-Miki, K. Kansaku, N. Itami, K. Shirasuna, T. Kuwayama, H. Iwata.
Follicular factors determining granulosa cell number and developmental competence of porcine oocytes. J Assist Reprod Genet. 2018. 35(10): 1809-1819. doi: 10.1007/s10815-018-1247-9.
N. Itami, K. Shirasuna, T. Kuwayama, H. Iwata.
Short-term heat stress induces mitochondrial degradation and biogenesis and enhances mitochondrial quality in porcine oocytes. J Therm Biol. 2018. 74: 256-263. doi: 10.1016/j.jtherbio.2018.04.010.
K. Kansaku, Y. Munakata, N. Itami, K. Shirasuna, T. Kuwayama, H. Iwata.
Mitochondrial dysfunction in cumulus-oocyte complexes increases cell-free mitochondrial DNA. J Reprod Dev. 2018. 64(3): 261-266. doi: 10.1262/jrd.2018-012.
K. Seno, N. Tanikawa, H. Takahashi, A. Ohkuchi, H. Suzuki, S. Matsubara, H. Iwata, T. Kuwayama, K. Shirasuna.
Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cells. American Journal of Reproductive Immunology. 2018. doi: 10.1111/aji.12826.
N. Itami, K. Shirasuna, T. Kuwayama, H. Iwata.
Palmitic acid induces ceramide accumulation, mitochondrial protein hyper-acetylation and mitochondrial dysfunction in porcine oocytes. Biology of Reproduction. 2018. doi: 10.1093/biolre/ioy023
K. Ogawa, N. Itami, M. Ueda, K. Kansaku, K. Shirasuna, T. Kuwayama, H. Iwata.
Non-esterified fatty acid-associated ability of follicular fluid to support porcine oocyte maturation and development. Reproductive Medicine and Biology. 2018. doi: 10.1002/rmb2.12084
総説
K. Shirasuna, T. Karasawa, M. Takahashi.
Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes. J Cell Physiol. 2019. 234(5): 5436-5450. doi: 10.1002/jcp.27475.
2017
原著論文
K. Kansaku#, S. Takeo#, N. Itami, A. Kin, K. Shirasuna, T. Kuwayama, H. Iwata.
Maternal aging affects oocyte resilience to carbonyl cyanide-m-chlorophenylhydrazone -induced mitochondrial dysfunction in cows. PLoS ONE. 2017. doi: 10.1371/journal.pone.0188099
T. Hayashi, S. Ueda, M. Mori, T. Baba, T. Abe, H. Iwata.
Influence of resveratrol pretreatment on thawed bovine embryo quality and mitochondrial DNA copy number. Theriogenology. 2017. doi: 10.1016/j.theriogenology.2017.10.022
N. Tanikawa, K. Seno, R. Kawahara-Miki, K. Kimura, S. Matsuyama, H. Iwata, T. Kuwayama, K. Shirasuna.
Interferon tau regulates cytokine production and cellular function in human trophoblast cell line. Journal of Interferon & Cytokine Research. 2017. doi: 10.1089/jir.2017.0057
K. Kansaku, N. Itami, R. Kawahara-Miki, K. Shirasuna, T. Kuwayama, H. Iwata.
Differential effects of mitochondrial inhibitors on porcine granulosa cells and oocytes. Theriogenology. 2017. doi: 10.1016/j.theriogenology.2017.07.049
N. Tanikawa, A. Ohtsu, R. Kawahara-Miki, K. Kimura, S. Matsuyama, H. Iwata, T. Kuwayama, K. Shirasuna.
Age-associated mRNA expression changes in bovine endometrial cells in vitro. Reproductive Biology and Endocrinology. 2017. doi: 10.1186/s12958-017-0284-z
T. Abe#, R. Kawahara-Miki#, T. Hara, T. Noguchi, T. Hayashi, S. Shirasuna, T. Kuwayama, H. Iwata.
Modification of mitochondrial function, cytoplasmic lipid content and cryosensitivity of bovine embryos by resveratrol. Journal of Reproduction and Development. 2017. doi: 10.1262/jrd.2016-182
K. Seno, S. Sase, A. Ozeki, H. Takahashi, A. Ohkuchi, H. Suzuki, S. Matsubara, H. Iwata, T. Kuwayama, K. Shirasuna.
Advanced glycation end products regulate interleukin-1b production in human placenta. Journal of Reproduction and Development. 2017. doi: 10.1262/jrd.2017-032
A. Ohtsu, H. Tanaka, K. Seno, H. Iwata, T. Kuwayama, K. Shirasuna.
Palmitic acid stimulates interleukin-8 via the TLR4/NF-kB/ROS pathways and induces mitochondrial dysfunction in bovine oviduct epithelial cells. American Journal of Reproductive Immunology. 2017. doi: 10.1111/aji.12642
A. Kin, K. Kansaku, M. Sumiya, N. Itami, K. Shirasuna, T. Kuwayama, H. Iwata.
Effect of aging on telomeres of oocytes and granulosa cells in cows. Journal of Mammalian Ova Research. 2017. doi.org/10.1274/032.034.0101
Y. Munakata, R. Kawahara-Miki, K. Shirasuna, T. Kuwayama, H. Iwata.
Polyacrylamide gel as a culture substrate improves in vitro oocyte growth from porcine early antral follicles. Molecular Reproduction and Development. 2017. doi: 10.1002/mrd.22758
N. Itami, Y. Munakata, K. Shirasuna, T. Kuwayama, H. Iwata.
Promotion of glucose utilization by insulin enhances granulosa cell proliferation and developmental competence of porcine oocyte grown in vitro. Zygote. 2017. doi: 10.1017/S0967199416000356
総説
H. Iwata.
Age-associated changes in granulosa cells and follicular fluid in cows. Journal of Reproduction and Development. 2017.
K. Shirasuna, H. Iwata.
Effect of aging on the female reproductive function. Contraception and Reproductive Medicine. 2017.
2016
原著論文
H. Tanaka#, A. Ohtsu#, S. Shiratsuki, R. Kawahara-Miki, H. Iwata, T. Kuwayama, K. Shirasuna#.
Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. Molecular Reproduction and Development. 2016. doi: 10.1002/mrd.22693
S. Shiratsuki, T. Hara, Y. Munakata, K. Shirasuna, T. Kuwayama, H. Iwata.
Low oxygen level increases proliferation and metabolic changes in bovine granulosa cells. Morecular and Celluar Endocrinology. 2016. doi.org/10.1016/j.mce.2016.08.010
M. Sugiyama, M. Sumiya, K. Shirasuna, T. Kuwayama, H. Iwata.
Addition of granulosa cell mass to the culture medium of oocytes derived from early antral follicles increases oocyte crowth, ATP content, and acetylation of H4K12. Zygote. 2016. doi.org/10.1017/S0967199416000198
Y. Munakata, T. Ichinose, K. Ogawa, N. Itami, H. Tasaki, K. Shirasuna, T. Kuwayama, H. Iwata.
Relationship between the number of cells surrounding oocytes and energy states of oocytes. Theriogenology. 2016. doi: 10.1016/j.theriogenology.2016.05.036
K. Shirasuna, H. Takano, K. Seno, A. Ohtsu, T. Karasawa, M. Takahashi, A. Ohkuchi, H. Suzuki, S. Matsubara, H. Iwata, T. Kuwayama.
Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells. Journal of Reproductive Immunology. 2016. doi.org/10.1016/j.jri.2016.06.001
阿部 崇人, 田中 裕史, 白砂 孔明, 桑山 岳人, 岩田 尚孝.
肝臓疾患を有するホルスタイン種の卵子の能力はレスベラトロールにより改善する. 日本胚移植学雑誌. 2016. 38: 1-9
Y. Munakata, R. Kawahara-Miki, S. Shiratsuki, H. Tasaki, N. Itami, K. Shirasuna, T. Kuwayama, H. Iwata.
Gene expression patterns in granulosa cells and oocytes at various stages of follicle development as well as in in vitro grown oocyte-and-granulosa cell complexes. Journal of Reproduction and Development. 2016. doi.org/10.1262/jrd.2016-022
A. Ohtsu, Y. Shibutani, K. Seno, H. Iwata, T. Kuwayama, K. Shirasuna.
Advanced glycation end products and lipopolysaccharide stimulate interleukin-6 secretion via RAGE/TLR4-NF-κB-ROS pathways and resveratrol attenuates these inflammatory responses in mouse macrophages. Experimental and Therapeutic Medicine. 2016. doi.org/10.3892/etm.2017.5045
K. Shirasuna#, K. Seno#, A. Ohtsu, S. Shiratsuki, A. Ohkuchi, H. Suzuki, S. Matsubara, S. Nagayama, H. Iwata, T. Kuwayama.
AGEs and HMGB1 increase inflammatory cytokine production from human placental cells, resulting in an enhancement of monocyte migration. American Journal of Reproductive Immunology. 2016. doi: 10.1111/aji.12506
H. Tanaka, S. Takeo, T. Abe, A. Kin, K. Shirasuna, T. Kuwayama, H. Iwata.
Liver condition of Holstein cows affects mitochondrial function and fertilization ability of oocytes. Journal of Reproduction and Development. 2016. doi.org/10.1262/jrd.2015-143